GQ-Pat SNP


A database of patented single nucleotide polymorphisms (SNPs)

GQ-Pat SNP is a new GenomeQuest database of patented single nucleotide polymorphisms (SNPs) available both for keyword and sequence searching. Sequence searches are run against the sequence created by including the 500 nucleotides on either side of the polymorphism.

Sequence search against GQ-Pat is used to find prior art where a pure keyword search returns incomplete results. GQ-Pat SNP goes one step further, building genomic sequences for patents that imply polymorphisms using SNP ids but don’t include them in the sequence listing.

GQ-Pat SNP enables IP searchers to identify prior art that at best is buried under mountains of documents in a keyword search, and at worst not identifiable at all without a sequence search.

Perform keyword and sequence searches against SNPs

For pharmaceutical, biotechnology, and diagnostic companies that build personalized medicine products, GQ-Pat SNP can ensure Freedom to Operate in this rapidly accelerating field. GQ-Pat SNP is a database of patents that refer to single nucleotide polymorphisms anywhere within the full text of the document. Sequence searches are run against the sequence created by including the 500 nucleotides on either side of the polymorphism locus. Keyword searches can also be run against the SNP ids (either RSIDs or Celera IDs).



By the Numbers

5,480 documents

300,307 sequences

2000+ assignees

A record returned from a sequence search against GQ-Pat SNP

Key benefits and features


  • Identify sequence-based prior art in documents that don’t necessarily list the sequences
  • Run direct keyword searches using RSIDs or Celera IDs
  • Run joint searches across GQ-Pat SNP and GQ-Pat, unifying the search into a single result
  • Contains all fields available in GQ-Pat
  • Includes fields related to SNPs such as the polymorphism, the gene(s) in which it occurs, and links to comprehensive NCBI reports on the SNP

GQ-Pat SNP solves a critical need for pharmaceutical companies building companion dagnostics, diagnostic companies selling sequence-based tests, and biotechnology companies in the field of personalized medicine.

Prior Art Hard to Find Anywhere Else


During a clinical trial for a myocardial infarction drug, a biotechnology company discovered a polymorphism in a protein tyrosine phosphatase gene called PTPN22 that correlates to susceptibility to coronary artery disease and response to therapeutic treatment. The company believes it may be able to develop intellectual property around companion diagnostics that relate to the polymorphism in question and asks the IP team to assess their freedom to operate. Keyword searches on terms like “PTPN22,” or “coronary artery disease,” or “polymorphism” bring back data sets of many thousands of documents.

Already a GQ-Pat customer, the IP team naturally turns next to sequence search against GQ-Pat. They build a 1,001 bp construct that consists of the polymorphism at position 501, and 500 nucleotides of the genomic sequence that flanks the polymorphism on either side. They then compare this sequence against GQ-Pat, seeking only very high-identity hits to localize the query specifically on the genome.

Building the query sequence

 

The GQ-Pat search finds exactly three patent families that have greater than 90% identity to this query and claimed sequences. One relates to rheumatoid arthritis, the second to detection of human enzyme proteins, and the third is a broad patent on non-coding RNAs. None reflect anything to do with coronary artery disease. Freedom to operate?

No meaningful coronary artery results against GQ-Pat...

 

The same sequence search again GQ-Pat SNP produces 59 patents with 99.9% similarity to the query. And after a brief filter to weed out irrelevant documents, the team identifies a patent from 2010 which precisely covers the invention – the prior art is significant.

...but perfect alignments to GQ-Pat SNP...

 

Sequence search against GQ-Pat is used to find prior art where a pure keyword search returns incomplete results. GQ-Pat SNP goes one step further, building genomic sequences for patents that imply polymorphisms using SNP ids but don’t include them in the sequence listing.

GQ-Pat SNP enables IP searchers to identify prior art that at best is buried under mountains of documents in a keyword search, and at worst not identifiable at all without a sequence search.

...yielding highly relevant subject matter not found elsewhere.